








Among adults aged 18–44 undergoing a first colorectal cancer (CRC) screening, a pre-screening AST below 14 U/L was associated with a 65% higher likelihood of an early-onset CRC diagnosis, and an ALT below 14 U/L with a 68% higher likelihood, each compared with patients whose values fell in the range of 14–29 U/L.


Among women seen in outpatient care, the rate of hormone therapy (HT) use rose from 1.7% in January 2017 to 3.6% in April 2026, a near-doubling. The increase was modest through 2022 and then accelerated sharply from 2023 onward.

Among adult patients living in states that have legalized sports betting, the quarterly rate of diagnosed gambling disorder rose from 3.0 per 100,000 patients in Q1 2018 to 4.8 per 100,000 in Q1 2026, around a 61% increase.

Among the U.S. holidays studied, Independence Day had the largest overall increase in injuries, averaging 5,418 more injuries than baseline over the three-day holiday window. Fireworks/blast injuries rose to 22 times baseline (1,187 more cases), burns were 1.8 times baseline (1,267 more cases), and fire/smoke exposures were 2.3 times baseline (383 more cases).